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HelpTest Code LAB1048 NMR LipoProfile w/IR Markers
Additional Codes
| Mayo Test ID |
|---|
| FNIRM |
Reporting Title
NMR LipoProfile w/IR Markers
Methodology
Nuclear Magnetic Resonance (NMR)
Performing Laboratory
BURI: LabCorp Burlington Interface
Specimen Requirements
Specimen Minimum Volume
1 mL
Specimen Required
Submit only one of the following specimens:
Serum
Draw blood in a plain red-top tube(s). (Serum gel tube is not acceptable.) Spin down and send 1 mL serum refrigerate in a plastic vial.
Note: 1. Patient should be fasting (12-14 hours)
2. Specimen must be received at LabCorp within 6 days of collection.
3. Label specimen appropriately (serum).
Plasma
Draw blood in a (lavender-top) EDTA tube(s). (Plasma gel tube is not acceptable.) Spin down and send 1 mL plasma refrigerate in a plastic vial.
Note: 1. Patient should be fasting (12-14 hours)
2. Specimen must be received by LabCorp within 6 days of collection.
3. Label specimen appropriately (plasma).
Reject Due To
|
Hemolysis |
Mild OK; Gross reject |
|
Thawing |
NA |
|
Lipemia |
NA |
|
Icterus |
NA |
|
Other |
Serum separator tube (SST), Plasma Separator tube (PST), frozen specimen, warm/room temperature specimen |
Specimen Stability
|
Specimen |
Temperature |
Time |
|
Varies |
Refrigerated |
6 days |
Reference Values
LDL Particle Number
LDL-P <1000 nmol/L
|
Low: |
<1000 nmol/L |
|
Moderate: |
1000 - 1299 |
|
Borderline-High: |
1300 - 1599 |
|
High: |
1600 - 2000 |
|
Very High: |
>2000 |
Lipids
LDL-C
|
0 - 19 years |
0 - 109 mg/dL |
|
|
|
|
>19 years |
0 - 99 mg/dL |
|
Optimal: |
<100 |
|
Above Optimal: |
100 - 129 |
|
Borderline: |
130 - 159 |
|
High: |
160 - 189 |
|
Very High: |
>189 |
|
|
|
Comment: LDL-C is inaccurate if patient is non-fasting.
|
HDL-C |
>39 mg/dL |
|
Triglycerides |
|
|
0 - 9 yrs: |
0 - 74 mg/dL |
|
10 - 19 yrs: |
0 - 89 mg/dL |
|
>19 years |
0 - 149 mg/dL |
|
|
|
Total Cholesterol
|
0 - 19 yrs: |
100 - 169 mg/dL |
|
|
|
|
>19 years |
100 - 199 mg/dL |
LDL and HDL Particles
|
HDL-P (Total) |
>or= 30.5 umol/L |
|
Small LDL-P |
<or= 527 nmol/L |
|
LDL Size |
>20.5 nm |
PARTICLE CONCENTRATION AND SIZE
<-- Lower CVD Risk Higher CVD Risk-->
LDL AND HDL PARTICLES Percentile in Reference Population
|
HDL-P (total) |
High |
75th |
50th |
25th |
Low |
|
|
>34.9 |
34.9 |
30.5 |
26.7 |
<26.7 |
|
Small LDL-P |
Low |
25th |
50th |
75th |
High |
|
|
<117 |
117 |
527 |
839 |
>839 |
LDL Size <-- Large (Pattern A) --> <-- Small (Pattern B) -->
|
|
23.0 |
20.6 |
20.5 |
19.0 |
|
Comment: Small LDL-P and LDL Size are associated with CVD risk, but not after LDL-P is taken into account.
These assays were developed and their performance characteristics determined by LipoScience. These assays not been cleared by the US Food and Drug Administration. The clinical utility of these laboratory values have not been fully established.
Insulin Resistance and Diabetes Risk
|
Large VLDL-P |
<or= 2.7 nmol/L |
|
Small LDL-P |
<or= 527 nmol/L |
|
Large HDL-P |
>or = 4.8 umol/L |
|
VLDL Size |
<or= 46.6 nm |
|
LDL Size |
>or= 20.8 nm |
|
HDL Size |
>or= 9.2 nm |
Insulin Resistance Score
LP-IR Score ≤ 45
Comment: LP-IR Score is inaccurate if patient is non-fasting.
INSULIN RESISTANCE/DIABETES RISK MARKERS
<--Insulin Sensitive Insulin Resistant -->
Percentile in Reference Population
|
Large VLDL-P |
Low |
25th |
50th |
75th |
High |
|
|
<0.9 |
0.9 |
2.7 |
6.9 |
>6.9 |
|
Small LDL-P |
Low |
25th |
50th |
75th |
High |
|
|
<117 |
117 |
527 |
839 |
>839 |
|
Large HDL-P |
High |
75th |
50th |
25th |
Low |
|
|
>7.3 |
7.3 |
4.8 |
3.1 |
<3.1 |
|
VLDL Size |
Small |
25th |
50th |
75th |
Large |
|
|
<42.4 |
42.4 |
46.6 |
52.5 |
>52.5 |
|
LDL Size |
Large |
75th |
50th |
25th |
Small |
|
|
>21.2 |
21.2 |
20.8 |
20.4 |
<20.4 |
|
HDL Size |
Large |
75th |
50th |
25th |
Small |
|
|
>9.6 |
9.6 |
9.2 |
8.9 |
<8.9 |
Insulin Resistance Score
|
LP-IR SCORE |
Low |
25th |
50th |
75th |
High |
|
|
<27 |
27 |
45 |
63 |
>63 |
The LP-IR score is a laboratory developed index that has been associated with insulin resistance and diabetes risk and should be used as one component of a physician's clinical assessment. Neither the LP-IR score nor the subclasses listed above have been cleared by the US Food and Drug Administration.
Day(s) Test Set Up
Monday through Friday
Analytic Time
1-3 days
CPT Code
80061
83704