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Test Code LAB35 Theophylline, Plasma or Serum

Additional Codes

46552

Reporting Title

Theophylline

Methodology

Roche Diagnostics-RMH, GMC

Siemens Diagnostics- HMH, MH

Performing Laboratory

OhioHealth Laboratory Services-RMH, GMC, HMH, MH Core Laboratories

Specimen Requirements

Collection Instructions:

1. Serum and Plasma gel tubes should be centrifuged within 2 hours of collection.

2. Red-top tubes should be centrifuged and aliquoted within 2 hours of collection.

 

Submit only 1 of the following specimens:

 

Preferred:

Serum

Draw blood in a gold-top serum gel tube(s). Spin down and send 1 mL of serum refrigerated. For theophylline SR tabs, trough specimen is usually drawn just prior to next oral dose; and peak specimen is usually drawn 4 hours after dose. For theophylline continuous infusion, trough specimen is usually drawn 24 hours after start of maintenance infusion; and peak specimen is usually drawn at 1/2 hour and 8 hours after loading dose and start of continuous infusion.

Note:  1. Date and time of draw is required on request form and specimen for processing.

2. A speckled-top serum gel tube (s) or a plain, red-top tube(s) is also acceptable.

3. Indicate serum on request form.

4. Label specimen appropriately (serum).

 

Alternate: Preferred for Siemens Users

Plasma

Draw blood in a mint green-top (heparin) gel tube(s). Spin down and send 1 mL of heparinized plasma refrigerated. For theophylline SR tabs, trough specimen is usually drawn just prior to next oral dose; and peak specimen is usually drawn 4 hours after dose. For theophylline continuous infusion, trough specimen is usually drawn 24 hours after start of maintenance infusion; and peak specimen is usually drawn at 1/2 hour and 8 hours after loading dose and start of continuous infusion.

Note:  1. Date and time of draw is required on request form and specimen for processing.

2. Indicate plasma on request form.

3. Label specimen appropriately (plasma).

Specimen Stability Information

Specimen Type Temperature Time
Serum or plasma Refrigerated 1 week capped
  Ambient   
  Frozen  60 days capped

 

 

Specimen Transport Temperature

Refrigerate/Ambient OK/Frozen OK

Reference Values

Therapeutic concentration

0-4 months:  6-14 mcg/mL

>4 months:  5-15 mcg/mL

Critical values 0-4 months:  >16 mcg/mL >4 months:  >20 mcg/mL

Alerting category: Always called within 1 hour

Day(s) Test Set Up

Monday through Sunday; Continuously

Test Classification and CPT Coding

80198