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Test Code LAB43 Acetaminophen, Plasma or Serum

Additional Codes

ACTM

Reporting Title

Acetaminophen

Methodology

Roche Diagnostics - RMH, BH, DH, DMH, GCMH, GMC, GMH, MGH, MH, OBH, PMH, WECC, HMH, SH

Acetaminophen overdose can cause hepatotoxicity and nephrotoxicity.

 

Van Wert Only: 

Methodology: ACTM reagent, when used in conjunction with SYNCHRON LX® System(s), UniCel® DxC 860i System(s) and SYNCHRON® Systems Drug Calibrator 2 set, is intended for quantitative determination of Acetaminophen concentration in human serum or plasma.

Performing Laboratory

OhioHealth Laboratory Services - RMH, BH, DH, DMH, GCMH, GMC, GMH, HMH, MGH, MH, OBH, PMC, SH, WECC and VWH Core Laboratories

Specimen Requirements

Submit only 1 of the following specimens:

 

Preferred:

Serum

Draw blood in a gold-top serum gel tube(s). Spin down and send 1 mL of serum refrigerated. Avoid hemolysis.
Note:

1. A speckled-top serum gel tube (s) or a plain, red-top tube(s) is also acceptable.

2. Indicate serum on request form.

3. Label specimen appropriately (serum).

 

Alternate: Preferred for VWH Lab:

Plasma

Draw blood in a mint green-top (heparin) gel tube(s). Spin down and send 1 mL of heparinized plasma refrigerated. Avoid hemolysis.

Note: 

1. Indicate plasma on request form.

2. Label specimen appropriately (plasma).

VWH Lab:

3. Tubes of blood are to be kept closed at all times and in a vertical position. It is recommended that the serum or plasma be physically separated from contact with cells within two hours from the time of collection.

4. Separated serum or plasma should not remain at room temperature longer than 8 hours. If assays are not completed within 8 hours, serum or plasma should be stored at +2°C to +8°C for up to 48 hrs. 

Specimen Stability Information for Roche:

Specimen Type Temperature Time
Serum or plasma Refrigerated 7 days capped
  Ambient  24 hours capped
  Frozen  6 months capped

 

Specimen Transport Temperature

Refrigerate/Ambient NO/Frozen OK

Reference Values

Therapeutic concentration:  10-30 mcg/mL

Critical values  >50 mcg/mL

Alerting category: Always called within 1 hour

 

Toxic level, potentially toxic at:

>200 mcg/mL (4 hours post dose)

>100 mcg/mL (8 hours post dose)

>50 mcg/mL (12 hours post dose)

The level at which toxicity occurs decreases with increasing half-lives until it is encountered at values as low as 50 mcg/mL when the half-life is 12 hours. Amitriptyline and imipramine falsely lower test results.

 

Van Wert Only: 

Reference Values:

10–30 µg/mL

 

Critical Values:

>149 µg/mL

Day(s) Test Set Up

Monday through Sunday; Continuously

Test Classification and CPT Coding

80143