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Test Code LAB458 Cytoplasmic Neutrophil Antibodies, Serum (ANCA)

Reporting Title

Anti-Neutrophil Cytoplasmic Antibody

Methodology

INOVA Diagnostics, Inc., Immunofluorescence Assay (IFA)

Two antineutrophil cytoplasmic antibodies (ANCA) patterns are detectable with this method. Cytoplasmic ANCA (cANCA) is suggestive of Wegner’s granulomatosis and to lesser extent microscopic polyarteritis. Perinuclear ANCA (pANCA) is associated with crescentic or rapidly progressive glomerulonephritis.

Note:  1. If positive for cANCA, a titer will be performed and a reflex proteinase 3 (PR-3) and Myeloperoxidase antibody (MPO) will be performed at an additional charge.

2. If positive for pANCA, a reflex myeloperoxidase (MPO) antibodies and a PR3 will be performed at an additional charge.

Performing Laboratory

OhioHealth Laboratory Services-RMH Special Testing

Specimen Requirements

Draw blood in a gold-top serum gel tube(s). (Grossly hemolyzed specimen is not acceptable.) Spin down and send 1 mL of serum refrigerated.

Note: A speckled-top serum gel tube (s) or a plain, red-top tube(s) is also acceptable.

Specimen Transport Temperature

Refrigerate/Ambient OK/Frozen OK

Reference Values

Negative (<20)

If positive for cANCA, results are titered.

Day(s) Test Set Up

Monday through Friday day shift only

Test Classification and CPT Coding

86036 x 2 - screen

886037 - (if appropriate)

 

86256 - titer (if appropriate)