Test Code LAB578 Prostate-Specific Antigen (PSA)-Monitor, Plasma or Serum
Reporting Title
PSA MonitorTM
Methodology
Roche Diagnostics, Electrochemiluminescence Immunoassay- RMH, MGH, MH
Results from assays produced by different manufacturers may not be comparable
Useful For
PSA Monitor is useful in evaluating patients with documented prostate problems in whom multiple prostate-specific antigen tests may be necessary per year.
Monitoring patients with a history of prostate cancer as an early indicator of recurrence and response to treatment.
Performing Laboratory
OhioHealth Laboratory Services-RMH, MH and MGH Core Laboratories
Specimen Requirements
Due to interference, patients receiving high doses of biotin (>5 mg/day) should wait at least 8 hours after dose before having blood drawn.
Collection Instructions:
1. Serum and Plasma gel tubes should be centrifuged within 2 hours of collection.
2. Red-top tubes should be centrifuged and aliquoted within 2 hours of collection.
Submit only 1 of the following specimens:
Preferred:
Serum
Draw blood in a gold-top serum gel tube(s). Spin down and send 1 mL of serum refrigerated.
Note:
1. A speckled-top serum gel tube (s) or a plain, red-top tube(s) is also acceptable.
2. Draw specimen before biopsy, prostatectomy, or prostate massage since manipulation of prostate may lead to elevated PSA levels persisting up to 3 weeks.
3. Patients receiving therapy with mouse monoclonal antibodies may have erroneous results.
4. Indicate serum on request form.
5. Label specimen appropriately (serum).
Alternate: Preferred by Siemens Users
Plasma
Draw blood in a mint green-top (lithium heparin) gel tube(s) or a lavender-top (EDTA) tube(s). Spin down and send 1 mL of heparinized or EDTA plasma refrigerated.
Note: 1. Draw specimen before biopsy, prostatectomy, or prostate massage since manipulation of prostate may lead to elevated PSA levels persisting up to 3 weeks.
2. Patients receiving therapy with mouse monoclonal antibodies may have erroneous results.
3. Indicate plasma on request form.
4. Label specimen appropriately (plasma).
Specimen Stability Information
Specimen Type | Temperature | Time |
---|---|---|
Serum or plasma | Refrigerated | 5 days |
Ambient | ||
Frozen | 6 months |
Specimen Transport Temperature
Ambient/Refrigerate/Frozen
Reference Values
TOTAL PSA- Recommended guidlines from the National Cancer Comprehensive Network (NCCN), 2016
PSA 0.00-0.99 ng/mL for ages ≤ 75
PSA 0.00-3.00 ng/mL for ages >75
All PSA results will flag as high in men age 75 and younger with an interpretive comment based on age and PSA value. The comment will list the recommendation of the NCCN.
The new recommendations put forth by the NCCN are to obtain a baseline PSA level for men age 45-75. The frequency of subsequent screening is dictated by the baseline result. If the result is <1.0 ng/mL, repeat testing every 2-4 years. If the result is between 1.00-3.00 ng/mL, repeat testing every 1-2 years. PSA values >3.00 ng/mL are considered positive regardless of age. PSA testing in men over 75 should only be considered in very select patient. Very few men in this age group benefit from PSA screening.
Serum markers are not specific for malignancy, and values may vary by method.
Note: Hormonal therapy may alter PSA expression, therefore, a low result following hormonal therapy may not adequately reflect the presence of residual or recurrent disease.
Day(s) Test Set Up
Monday through Sunday; Continuously
Test Classification and CPT Coding
84153