Test Code LAB821 Celiac Disease Serology Cascade, Serum
Additional Codes
Mayo Test ID |
---|
CDSP |
48403
Reporting Name
Celiac Disease Serology CascadeUseful For
Evaluating patients suspected of having celiac disease, including patients with compatible symptoms, patients with atypical symptoms, and individuals at increased risk (family history, previous diagnosis with associated disease, positivity for HLA-DQ2 and/or DQ8)
Profile Information
Test ID | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
IGA | Immunoglobulin A (IgA), S | Yes | Yes |
CDSP1 | Celiac Disease Interpretation | No | Yes |
Reflex Tests
Test ID | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
EMA | Endomysial Abs, S (IgA) | Yes | No |
DAGL | Gliadin(Deamidated) Ab, IgA, S | Yes | No |
TTGG | Tissue Transglutaminase Ab, IgG, S | Yes | No |
DGGL | Gliadin(Deamidated) Ab, IgG, S | Yes | No |
TTGA | Tissue Transglutaminase Ab, IgA, S | Yes | No |
Testing Algorithm
If the IgA result is within the age-specified normal range, then tissue transglutaminase (tTG) IgA antibody testing will be performed at an additional charge.
If the tTG IgA antibody result is equivocal, then endomysial IgA and deamidated gliadin IgA antibody testing will be performed at an additional charge.
If the IgA result is greater or equal to 1.0 mg/dL but lower than the age-specified normal range, then tTG IgA, tTG IgG, deamidated gliadin IgA, and deamidated gliadin IgG antibody testing will be performed at an additional charge.
If the IgA result is below the limit of detection (<1.0 mg/dL), then tTG IgG and deamidated gliadin IgG antibody testing will be performed at an additional charge.
The following algorithms are available:
Performing Laboratory
Mayo Clinic Laboratories in RochesterSpecimen Type
SerumOrdering Guidance
This cascade should not be used in patients who have previously been or are currently being treated with a gluten-free diet. For these individuals, order CDGF / Celiac Disease Gluten-Free Cascade, Serum and Whole Blood.
This cascade should not be used in individual who are negative for HLA-DQ2 or DQ8, as a diagnosis of celiac disease is unlikely. For individuals who are positive for either HLA-DQ2 and/or DQ8, this test may be ordered to assess for the presence of autoantibodies associated with celiac disease.
Cascade testing is recommended for celiac disease. Cascade testing ensures that testing proceeds in an algorithmic fashion. The following cascades are available, select the appropriate one for your specific patient situation.
-CDCOM / Celiac Disease Comprehensive Cascade, Serum and Whole Blood: Complete testing including HLA DQ
-CDSP / Celiac Disease Serology Cascade, Serum: Complete serology testing excluding HLA DQ
-CDGF / Celiac Disease Gluten-Free Cascade, Serum and Whole Blood: For patients already adhering to a gluten-free diet
To order individual tests, see Celiac Disease Diagnostic Testing Algorithm
Specimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 5 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
2 mL
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Serum | Refrigerated (preferred) | 14 days | |
Frozen | 21 days |
Special Instructions
Reference Values
Immunoglobulin A (IgA)
0-<5 months: 7-37 mg/dL
5-<9 months: 16-50 mg/dL
9-<15 months: 27-66 mg/dL
15-<24 months: 36-79 mg/dL
2-3 years: 27-246 mg/dL
4-6 years: 29-256 mg/dL
7-9 years: 34-274 mg/dL
10-14 years: 42-295 mg/dL
13-15 years: 52-319 mg/dL
16-17 years: 60-337 mg/dL
≥18 years: 61-356 mg/dL
Test Classification
See Individual Test IDsCPT Code Information
82784
86258 (if appropriate)
86364 (if appropriate)
86231 (if appropriate)
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
CDSP | Celiac Disease Serology Cascade | 94494-2 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
IGA | Immunoglobulin A (IgA), S | 2458-8 |
28991 | Celiac Disease Interpretation | 69048-7 |
Report Available
7 to 9 daysMethod Name
Nephelometry
Forms
If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-General Request (T239)
Day(s) Performed
Profile tests: Monday through Friday; Reflex tests: Monday through Saturday