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Test Code LAB874 Cyclosporine, Blood

Important Note

 Send whole blood specimen in original tube. Do not aliquot.

Reporting Title

Cyclosporine Level

Performing Laboratory

OhioHealth Laboratory Services - RMH Special Testing

Methodology

Enzyme immunoassay

Specimen Collection

Container/Tube: Lavender top (EDTA)

Specimen Volume: 3 mL

Collection Instructions:

1. Collect specimen immediately before a scheduled dose.

2. Do not centrifuge.

3. Send whole blood specimen in original tube. Do not aliquot.

Additional Information: Therapeutic range applies to trough specimens collected immediately prior to a.m. dose.

Reference Values

100-400 ng/mL (trough)

Target steady-state trough concentrations vary depending on the type of transplant, concomitant immunosuppression, clinical/institutional protocols, and time post-transplant. Results should be interpreted in conjunction with this clinical information and any physical signs/symptoms of rejection/toxicity.

Day(s) Performed

Monday through Sunday, Dayshift

Specimen Transport and Storage

Refrigerated (preferred) 7 days, Frozen 30 days, Ambient NO

CPT Coding

80158 

Clinical Information

Useful For:

Monitoring whole blood cyclosporine concentration during therapy, particularly in individuals coadministered cytochrome P450 (CYP) 3A4 substrates, inhibitors, or inducers

 

Adjusting dose to optimize immunosuppression while minimizing toxicity

 

Evaluating patient compliance