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Test Code LAB90048 Cerebrospinal Fluid (CSF) IgG Synthesis

Important Note

BOTH Serum and spinal fluid are required for this test. It is preferred that the collection date and time to be the same for both CSF and serum; however, it is acceptable for them to be drawn within 48 hours of each other.

Additional Codes

45957

Reporting Title

IgG Synthesis (CSF)

Methodology

Immunoturbidimeric Assay

The IgG synthesis (CSF index) is useful in the diagnosis of individuals with multiple sclerosis.

Performing Laboratory

OhioHealth Laboratory Services-RMH Special Testing

Specimen Requirements

BOTH Serum and spinal fluid are required for this test. It is preferred that the collection date and time to be the same for both CSF and serum; however, it is acceptable for them to be drawn within 48 hours of each other.

 

Serum

Draw blood in a gold-top serum gel tube(s). Spin down and send 0.5 mL of serum refrigerated. 

Note:

1. A speckled-top serum gel tube (s) or a plain, red-top tube(s)

    Lithium Heparin and EDTA are also acceptable.

2. Label specimen appropriately (serum).

 

Spinal Fluid

Submit 1 mL of spinal fluid in a screw-capped, sterile, plastic vial. Send specimen refrigerated. Maintain sterility and forward promptly.

Note:  Label specimen appropriately (spinal fluid).

 

Specimen Stability Information:

Stable 3 days refrigerated

Specimen Transport Temperature

Refrigerate/Ambient OK/Frozen OK

Reference Values

IgG synthesis:  0-6 mg/day

CSF index:  0.4-0.53

Albumin index:  0.0-9.0

IgG index:  0.0-0.7

CSF IgG:  0-8.1 mg/dL

CSF albumin:  0-27.0 mg/dL

Serum IgG:  541-1,694 mg/dL

Serum albumin:  3,848-5,304 mg/dL

Day(s) Test Set Up

Monday through Saturday

Test Classification and CPT Coding

82040 - albumin, serum.

82042 - albumin, spinal fluid

 

Test Classification  Albumin-CSF

This test has been modified from the manufacturer’s instructions. Its performance characteristics were determined by OhioHealth Laboratory Services in a manner consistent with CLIA requirements.

 

82784 x 2 - IgG, serum and spinal fluid