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Test Code LAB91019 Lupus Anticoagulant Screen (OB)

Reporting Title

OB Lupus anticoagulant Screen

Methodology

Profile Information:
Unit Codes  Published Name  Available Separately
LAB320 PT/INR Yes
 LAB325 APTT Yes
    LAB90131 StaClot (Lupus Anticoagulant) Yes

    LAB90733

Beta-2 Glycoprotein 1 Antibodies, IgG

 Yes
    LAB90734 Beta-2 Glycoprotein 1 Antibodies, IgM Yes

LAB319

Dilute Russell Viper Venom Time (DRVVT) (and confirmation if appropriate)

Yes

LAB464

Phospholipid Antibodies (Cardiolipin Antibodies)

Yes

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

        This panel should be ordered on patients presenting with thrombosis not clinically explained.

Performing Laboratory

OhioHealth Laboratory Services-RMH Campus and Mayo Medical Laboratory

Specimen Requirements

Serum and sodium citrate blood are required for these tests.

 

Beta-2 Glycoprotein 1 Antibodies, IgG, IgM

Gold Top SST or Red-Top tube

 

Blood or Plasma for  DRVVT, PT/INR, APTT, and Hexagonal Phospholipid Neutralization (StaClot)

 

Submit only 1 of the following specimens:

 

Riverside Inpatients and Riverside Campus draw sites:

Testing must be performed within 4 hours of draw if submitting unprocessed whole blood.

Draw 3 full, light blue-top (citrate) tube; and send citrated whole blood. Invert several times to mix blood. Forward unprocessed whole blood promptly at ambient temperature only. Do not refrigerate. 

Note: 1. This assay requires its own specimen.

2. Gross hemolysis, icterus, and lipemia may affect results.

3. Indicate whole blood on request form.

4. Label specimen appropriately (whole blood).

 

Outpatients/Outreach Clients

Plasma-Frozen

Draw 3 full, light blue-top (citrate) tube. Spin down, remove plasma, spin plasma again, and place 1 mL of citrated platelet-poor plasma into separate plastic vials. (Glass vial is not acceptable.) Pour-off vial should be no more than 2/3 full. Send specimen frozen.

 

Note: 1. This assay requires its own specimen.

2. Double-centrifuged specimen is critical for accurate results as platelet contamination may cause spurious

    results.

3. Gross hemolysis, icterus, and lipemia may affect results.

4. Indicate plasma on request form.

5. Label specimen appropriately (plasma).

 

Serum or Plasma for Phospholipid Antibodies (Cardiolipin Antibodies)

 

Submit only 1 of the following specimens:

 

Serum

Draw blood in a gold-top or a speckled-top serum gel tube(s). (Hemolyzed or contaminated specimen is not acceptable.) Spin down immediately and send 1 mL of serum refrigerated.

Note:.

1. Plain, red-top tube(s) is also acceptable.

2. Label specimen appropriately (serum for phospholipid antibodies [cardiolipin antibodies]).

 

Plasma

Draw blood in a mint green-top (heparin) gel tube(s). (Hemolyzed or contaminated specimen is not acceptable.) Spin down immediately and send 1 mL of heparinized or EDTA plasma refrigerated.

Note:  1. Label specimen appropriately plasma for phospholipid antibodies [cardiolipin antibodies]).

Specimen Transport Temperature

Ambient/Refrigerate NO/Frozen NO-Blood

Frozen/Refrigerate NO/Ambient NO-Plasma

Refrigerate/Frozen OK/Ambient NO-Serum

Reference Values

BETA-2 GLYCOPROTEIN 1 ANTIBODIES, IgG, IgM

 <10.0 U/mL (negative)

10.0-14.9 U/mL (borderline)

≥15.0 U/mL (positive)

 

See individual test listings for all other tests.

Day(s) Test Set Up

PT/INR, APTT,  Monday through Sunday

Beta-2 Glycoprotein 1 Antibodies, IgG, IgM  Daily 8:00 am

Dilute Russell Viper Venom Time (DRVVT):  Monday through Friday

Phospholipid Antibodies (Cardiolipin Antibodies):  Monday and Thursday

Hexagonal Phospholipid Neutralization (StaClot):  Tuesday and Friday

Test Classification and CPT Coding

 

“Beta-2 Glycoprotein 1 Antibodies, IgG 86146

 “Beta-2 Glycoprotein 1 Antibodies, IgM 86146

“Dilute Russell Viper Venom Time (DRVVT)” 85613 - DRVVT

85613 x 2 - DRVVT confirmation (if appropriate)

“Phospholipid Antibodies (Cardiolipin Antibodies)” 86147 x 3

PT/INR 85610

APTT 85730

Hexagonal Phospholipid Neutralization (StaClot)  85598