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Test Code LBCS Labile Bound Copper, Serum


Ordering Guidance


If CUS1 / Copper, Serum is ordered with this test, it will be canceled, as copper testing will be automatically added as a part of this test order.



Specimen Required


Patient Preparation: High concentrations of gadolinium and iodine are known to potentially interfere with most inductively coupled plasma mass spectrometry-based metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for at least 96 hours.

Supplies:

-Metal Free Specimen Vial (T173)

-Metal Free B-D Tube (No Additive), 6 mL (T184)

Collection Container/Tube: 6-mL Plain, royal blue-top Vacutainer plastic trace element blood collection tube

Submission Container/Tube: 7-mL Metal-free, screw-capped, polypropylene vial

Specimen Volume: 0.75 mL

Collection Instructions:

1. For complete instructions, see Metals Analysis Specimen Collection and Transport.

2. Allow the specimen to clot for 30 minutes; then centrifuge the specimen to separate serum from the cellular fraction.

3. Remove the stopper. Carefully pour specimen into metal-free, polypropylene vial, avoiding transfer of the cellular components of blood. Do not insert a pipet into the serum to accomplish transfer, and do not ream the specimen with a wooden stick to assist with serum transfer.

4. Freeze sample on dry ice immediately after pouring off the serum.


Useful For

May be useful in the evaluation of copper-related disorders, including Wilson disease

Additional Tests

Test ID Reporting Name Available Separately Always Performed
CUS1 Copper, S Yes Yes

Testing Algorithm

After a labile bound copper serum result is obtained, a total copper serum test will be performed at an additional charge. The labile bound copper concentration will be divided by the total copper concentration to calculate the labile bound copper fraction result.

Method Name

Inductively-Coupled Plasma Mass Spectrometry (ICP-MS)

Reporting Name

Labile Bound Copper, S

Specimen Type

Serum

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Frozen 28 days METAL FREE

Reference Values

Labile Bound Copper: <105 ng/mL

 

Labile Bound Copper Fraction:

Males: <10.5 %

Females: <8.1 %

 

Copper, Total:

0-2 months: 40-140 mcg/dL

3-6 months: 40-160 mcg/dL

7-9 months: 40-170 mcg/dL

10-12 months: 80-170 mcg/dL

13 months-10 years: 80-180 mcg/dL

11-17 years: 75-145 mcg/dL

Males:

≥18 years: 73-129 mcg/dL

Females:

≥18 years: 77-206 mcg/dL

Day(s) Performed

Wednesday

Report Available

7 to 14 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

82525

LOINC Code Information

Test ID Test Order Name Order LOINC Value
LBCS Labile Bound Copper, S 105459-2

 

Result ID Test Result Name Result LOINC Value
620895 Labile Bound Copper, S 96257-1
620896 Labile Bound Copper Fraction 96463-5